Published in today's Federal Register (FR) is a Department of Transportation Notice of Proposed Rulemaking (NPRM). The NPRM is available on the FR web page at https://www.govinfo.gov/content/pkg/FR-2025-09-02/pdf/2025-16720.pdf. Today, we will post it on the Office of Drug and Alcohol Policy and Compliance (ODAPC) webpage at https://www.transportation.gov/odapc/frpubs. The proposals in the NPRM include: - Add Fentanyl and norfentanyl to the testing panels,
- Adjust laboratory morphine confirmatory cutoff (urine only),
- Remove the additional requirement for MROs to determine clinical evidence of illegal opioid (codeine and morphine use for urine and oral fluid),
- Add and modify certain definitions,
- Authorize biomarker testing,
- Modify analyte nomenclature for marijuana (urine and oral fluid),
- Revise footnote #1 to both testing panels to include more specific and updated criteria for alternate technology initial drug tests,
- Add a 30-day requirement for drug collectors, STTs, and BATS within which to complete the required training and mock collections,
- Adding a new 'fatal flaw' related to oral fluid specimens,
- Modify several provisions related to oral fluid specimens,
- Add clarifying language to other provisions (such as oral fluid collector training, SAP documents, and shy bladder/dry mouth procedures),
- Various technical amendments.
The comment period for the NPRM closes on October 17, 2025. Comments to the docket can be submitted using this link https://www.regulations.gov/docket/DOT-OST-2025-0049/document. U.S. Department of Transportation | 1200 New Jersey Avenue, SE | Washington DC 20590 | 855-368-4200 |  | |